Chromosomes contain both the raw code for life and the instructions for its use. We are interested in discovering the rules that govern chromosome structure and function at the molecular level. Our efforts are focused on how nucleosomes and chromosome-segregation machines are organized in situ. We test both old and new hypotheses of chromosome-related activities by perturbing cells and then observing their structural changes by electron cryotomography. Revolutionary technologies will help us learn about chromosome transactions in situ with unprecedented detail.


Nov 2020 - Cai Tong's serial cryosectioning + cryotomography bio-protocol is out!

Nov 2020 - Welcome to Tingsheng!

Jul 2020 - Welcome to Wen Guan, Joy, and Zeng Keong!

Jul 2020 - Welcome to Claris.

Feb 2020 - New grant to study meiotic nuclei = new postdoc position!