Chromosomes contain both the raw code for life and the instructions for its use. We are interested in discovering the rules that govern chromosome structure and function at the molecular level. Our efforts are focused on how nucleosomes and chromosome-segregation machines are organized in situ. We test both old and new hypotheses of chromosome-related activities by perturbing cells and then observing their structural changes by electron cryotomography. Revolutionary technologies will help us learn about chromosome transactions in situ with unprecedented detail.
Jan 2024 - Welcome to Vaishnavi and Jermaine.
Dec 2023 - Lu's essay on "negative" results is out in JCS.
Sep 2023 - Congrats to Dr. Zhi Yang Tan for successfully defending his thesis!
Aug 2023 - Jon & Tingsheng's in situ human chromatin work is on bioRxiv!
Jul 2023 - Zhi Yang, Shujun, Alex, and Jon's heterogeneous nucleosome paper is published in eLife!