Chromosomes contain both the raw code for life and the instructions for its use. We are interested in discovering the rules that govern chromosome structure and function at the molecular level. Our efforts are focused on how nucleosomes and chromosome-segregation machines are organized in situ. We test both old and new hypotheses of chromosome-related activities by perturbing cells and then observing their structural changes by electron cryotomography. Revolutionary technologies will help us learn about chromosome transactions in situ with unprecedented detail.
May 2021 - Meiotic triple helices are not SCs! See our revised preprint here.
Apr 2021 - Our new preprint shows that yeast nucleosome are non-canonical in situ!
Jan 2021 - Welcom to Weiping.
Dec 2020 - Farewell to Olivia. Best of luck on your next adventure!
Nov 2020 - Cai Tong's serial cryosectioning + cryotomography bio-protocol is out!