Welcome

Chromosomes contain both the raw code for life and the instructions for its use. We are interested in discovering the rules that govern chromosome structure and function at the molecular level. Our efforts are focused on how nucleosomes and chromosome-segregation machines are organized in situ. We test both old and new hypotheses of chromosome-related activities by perturbing cells and then observing their structural changes by electron cryotomography. Revolutionary technologies will help us learn about chromosome transactions in situ with unprecedented detail.