Chromosomes contain both the raw code for life and the instructions for its use. We are interested in discovering the rules that govern chromosome structure and function at the molecular level. Our efforts are focused on how nucleosomes and chromosome-segregation machines are organized in situ. We test both old and new hypotheses of chromosome-related activities by perturbing cells and then observing their structural changes by electron cryotomography. Revolutionary technologies will help us learn about chromosome transactions in situ with unprecedented detail.
Jan 2020 - Our MBoC Perspective on cryo-ET of eukaryotic cells is out.
Jan 2020 - Shujun & Zhi Yang's work on pombe G0 quiescent cells is on bioRxiv.
Nov 2019 - Congrats to Dr. Olivia Ma for a successful PhD defense!
Aug 2019 - Olivia's work on the synaptonemal complex is on bioRxiv!
Aug 2019 - We have a new grant = another new postdoc position!